The 21-aminosteroid antioxidant, U74389F, prevents estradiol-induced depletion of hypothalamic β-endorphin in adult female rats
Identifieur interne : 004206 ( Main/Exploration ); précédent : 004205; suivant : 004207The 21-aminosteroid antioxidant, U74389F, prevents estradiol-induced depletion of hypothalamic β-endorphin in adult female rats
Auteurs : Hyman M. Schipper [Canada] ; G. Clarissa Desjardins [Canada] ; Alain Beaudet [Canada] ; James R. Brawer [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1994.
English descriptors
- KwdEn :
Abstract
Abstract: A single intramuscular injection of 2 mg estradiol valerate (EV) results in neuronal degeneration and β-endorphin depletion in the hypothalamic arcuate nucleus of adult female rats. We have hypothesized that peroxidase-positive astrocytes in this brain region oxidize estrogens and catecholestrogens to semiquinone radicals which mediate oxidative neuronal injury. In the present study, dietary administration of the potent antioxidant 21-aminosteroid, U-74389F, completely blocked EV-induced β-endorphin depletion in the hypothalami of adult female rats. Neither EV nor 21-aminosteroid treatment had any effect on hypothalamic concentrations of neuropeptide Y and Met-enkephalin, confirming that the estradiol lesion is fairly selective for the β-endorphin cell population. The present findings support the hypothesis that the toxic effect of estradiol on hypothalamic β-endorphin neurons is mediated by free radicals.
Url:
DOI: 10.1016/0006-8993(94)90332-8
Affiliations:
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